DFU: pathogenesis and Microbiome interactions DFUs are a leading example of chronic wounds, arising from neuropathy, impaired vascularization, and persistent hyperglycemia
It takes time to reduce oxidative stress & pigment reduction internally
Thatikonda V, Lu H, Jurado S, Kostyrko K, Bristow CA, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Lieb S, Jeschko A, Machado AA, Marszalek ED, Mahendra M, Jaeger PA, Sorokin A, Strauss S, Trapani F, Kopetz S , Vellano CP, Petronczki M, Kraut N, Heffernan TP, Marszalek JR, Pearson M, Waizenegger I, Hofmann MH
CARERE, A., ORTALI, V.A., CARDAMONE, G., TORRACCA, A.M., & RASCHETTI, R
Less common reactions include contact dermatitis (a rash or itching that doesnt resolve), persistent redness, or a localized copper reaction
(2010) attempted to elucidate the potential mechanism by which BPC 157 stimulates the outgrowth and proliferation of tendon fibroblasts